Evolution of antimicrobial peptides including ...

Development of reliable and portable biosensors for detection of pathogenic bacteria can affect different areas: from

monitoring water quality testing of drugs strattera for bacterial infection. Of particular interest are detectors

, combining the natural features of biological recognition of the sensitive labels without electronic sensors reading. Evolution of antimicrobial peptides including showing broad spectrum activity against pathogenic bacteria while preserving

high degree of reliability. Here we report selective and sensitive detection of infectious agents by electronic >> << detection based on antimicrobial peptides microcapacitive functional arrays of electrodes. Semiselective antimicrobial peptide magainin

IBЂ "that naturally occurs in the skin of African pazurystyh frogsBЂ" was immobilized on gold microelectrodes through the C-terminal cysteine ​​residue >>. << Noteworthy that exposure of the sensor with different concentrations of pathogenic E. coli

revealed detection limits of approximately 1b bacteria / nјL, clinically useful detection range. Peptide-microcapacitive

hybrid device was further demonstrate how gram-selective detection and differentiation of interbacterial voltage

while maintaining the possibility of recognition by pathogenic strains of E. coli

and Salmonella. Finally, we report simulation BЂњwater-samplingBЂ "chip, which consists of running mikroflyuidnyh focus on integrated hybrid sensor >> << that demonstrates real-time embedded control interaction

E. coli cell antimicrobial peptides. The combination of reliable, given the evolution of peptides with an electronic readout electrodes

monitoring could open up exciting directions in fundamental studies of the interaction of bacteria with antimicrobial peptides >> << and practical use of these devices as portable detectors pathogen. .